Major: Animal Science

Faculty Mentor: Dr. Jennifer Hernandez Gifford 

Contact:

Research Project Summary:

Effect of repeated low dose Lipopolysaccharide (LPS) exposure on circulating Estradiol concentrations in nulliparous Rambouillet ewes.

Gram negative bacterial infections are well known to have major negative implications on female fertility. However, the severity of infection required before observing a decline in reproductive biomarkers such as estradiol remains unclear. Estradiol, a critical reproductive sex hormone, is essential for follicular development and ovulation. To better understand the effects of a subclinical infection, nulliparous ewes were repeatedly injected with a low dose of Lipopolysaccharide (LPS)-the endotoxin component of gram-negative bacteria throughout a 17-day estrous cycle. Blood samples were collected for 2 consecutive cycles and hormone concentrations were measured using radioimmunoassay techniques. By expanding our understanding of these endotoxins and their interaction within the body at low levels we can develop improved management strategies to protect the delicate hormonal balance within livestock and humans to optimize reproductive health. Such insights may ultimately enhance fertility outcomes, production efficiency, and the economic sustainability of livestock operations.